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煙曲霉毒素c |
| CAS No.: |
118974-02-0 |
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| 備注： |
中文名稱煙曲霉毒素c中文同義詞煙曲霉素C,來(lái)源于煙曲霉菌;煙曲酶毒素C;煙曲霉震顫素C;煙曲霉毒素C;煙曲霉素C;FUMITROMORGINC英文名稱FUMITREMORGINC英文同義詞FumitremorginC,Aspergillus.fumigatus-CAS118974-02-0-Calbiochem;FuMitreMorginCFuMitreMorg;(5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1’’,2’’:4’,5’]pyrazino[1’,2’:1,6]pyrido[3,4-b]indole-5,14-dione;12alpha-FumitremorginC;5H,14H-Pyrrolo[1’’,2’’:4’,5’]pyrazino[1’,2’:1,6]pyrido[3,4-b]indole-5,14-dione,1,2,3,5a,6,11,12,14a-octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-,(5aS,12S,14aS)-;FumitremorginC,98%,fromAspergillusfumigatus;12α-FumitremorginC;FumitremorginC,fromAspergillusfumigatusCAS號(hào)118974-02-0分子式C22H25N3O3分子量379.45EINECS號(hào)相關(guān)類別微生物代謝物;抗生素;生化試劑;生物堿;醫(yī)藥原料Mol文件118974-02-0.mol結(jié)構(gòu)式煙曲霉毒素c性質(zhì)熔點(diǎn)259.5-260.5℃沸點(diǎn)642.9±55.0°C(Predicted)密度1.34±0.1g/cm3(Predicted)儲(chǔ)存條件2-8°C溶解度乙腈：可溶5mg/mL酸度系數(shù)(pKa)17.16±0.40(Predicted)形態(tài)固體顏色白色至淺棕色煙曲霉毒素c用途與合成方法背景煙曲霉毒素是由串珠鐮刀菌（Fusariummoniliforme）產(chǎn)生，通常在霉變的玉米中發(fā)現(xiàn)，真菌毒素。煙曲霉毒素發(fā)現(xiàn)較晚，最早于1988年報(bào)告，最常見(jiàn)的是煙曲霉毒素B、煙曲霉毒素C。生物活性FumitremorChemicalbookginC是有效，選擇性的ABCG2/BRCP抑制劑。體外研究Multidrugresistance(MDR)isamajorproblemincancerchemotherapy.FumitremorginCisextremelyeffectiveinreversingresistancetomitoxantrone,doxorubicin,andtopotecaninmultidrug-selectedcelllines.InMCF-7/mtxR(amitoxantroneselectedcellline),fumitremorginCreversesmitoxantroneresistance(114-fold)anddoxorubicinresistance(3-fold).FumitremorginC(5/AM)significantlypotentiatesthetoxicityofmitoxantrone(93-fold),doxorubicin(26-fold),andtopotecan(24-fold)inS1M1-3.2cells.Reversalofresistanceisassociatedwithanincreaseindrugaccumulation.FumitremorginCdoesnotreversedrugresistanceincellswithelevatedexpressionofPgporMRP.FumitremorginCalmostcompletelyreversesresistancemediatedbyBCRPinvitroandisapharmacologicalprobefortheexpressionandmolecularactionofthistransporter.FumitremorginCalsoenhancesthetoxicityofmitoxantroneandtopotecaninvector-transfectedMCF-7cells(2.5–5.6fold).ItreducestheIC50oftopotecaninBCRP-overexpressingcellsbelowthatobservedintheuntreatedvector-transfectedcells.. |
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