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(2R,3R,4R)-2-羥甲基哌啶-3,4-二醇 |
| CAS No.: |
53185-12-9 |
| 分子式： |
C6H13NO3 |
| 分子量： |
147.1723 |
| 備注： |
中文名稱(2R,3R,4R)-2-羥甲基哌啶-3,4-二醇中文同義詞蕎麥堿;桑葉生物堿;(2R,3R,4R)-2-羥甲基哌啶-3,4-二醇;蕎麥堿,>98%;喬麥堿;FAGOMINE,蕎麥堿英文名稱fagomine英文同義詞fagomine;(2R)-2-(Hydroxymethyl)piperidine-3β,4α-diol;(2R)-2α-(Hydroxymethyl)piperidine-3β,4α-diol;(2R)-3β,4α-Dihydroxypiperidine-2α-methanol;1,2,5-Trideoxy-1,5-epimino-D-xylo-hexitol;(2R,3R,4R)-3,4-Dihydroxy-2-piperidinemethanol;(2R,3R,4R)-2-(Hydroxymethyl)piperidine-3,4-diol;D-FagoMineCAS號53185-12-9分子式C6H13NO3分子量147.17EINECS號相關(guān)類別植物提取物;對照品;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品Mol文件53185-12-9.mol結(jié)構(gòu)式(2R,3R,4R)-2-羥甲基哌啶-3,4-二醇性質(zhì)熔點185-186℃沸點315.4±42.0°C(Predicted)密度1.279形態(tài)固體酸度系數(shù)(pKa)14.16±0.60(Predicted)顏色白色至卡其色LogP-0.880(est)(2R,3R,4R)-2-羥甲基哌啶-3,4-二醇用途與合成方法生物活性Fagomine是一種溫和的糖苷酶(glycosidase)抑制劑，F(xiàn)agomine作用于Amyloglucosidase(A.niger)，β-Glucosidase(bovine)和Isomaltase(yeast)，Ki分別為4.8μM，39μM和Chemicalbook70μM。靶點Glycosidase體外研究Fagomine(D-fagomine)isaniminosugarthathasbeenshowntoselectivelyagglutinateEnterobacterialesinvitro.Fagomineselectivelyagglutinatesfimbriatedenterobacteria(e.g.,E.coli)andinhibitstheiradhesiontotheintestinalmucosa;thereasonforthisisprobablyrelatedtoitsstructuralsimilaritywithlectin-bindingsaccharides(e.g.,mannose).Fagomineiscapableofalteringthiseffectofhigh-fathigh-sucrosediet(HFHS)ontheproportionofEnterobacterialesandE.coli.體內(nèi)研究Fagomine(D-fagomine)isanaturaliminosugarthatcounteractstheshort-termeffectsofahigh-energy-densedietonbodyweight,fastingbloodglucoselevelsandtheproportionofgutEnterobacteriales.Comparetothestandardgroup,ratsfedhigh-fathigh-sucrosediet(HFHS)withFagomine(D-fagomine)gainsignificantlylessweight(15.3%)thanthosefedHFHS(20.9%). |
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