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HOECHST 34580 |
| CAS No.: |
23555-00-2 |
| 分子式： |
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| 分子量： |
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| 備注： |
中文名稱HOECHST34580中文同義詞赫斯特34580游離;N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1’H-[2,5’-聯(lián)苯并[D]咪唑]-2’-基)苯胺;化合物HOECHST34580;NO34580熒光染料;N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1’H-[2,5’-聯(lián)苯并[D]咪唑]-2’-基)苯胺英文名稱HOECHST34580英文同義詞HOECHST34580;HOE34580;ProaMine;2,50-bibenzimidazole,20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-;Benzenamine,N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5’-bi-1H-benzimidazol]-2’-yl]-;Hoechst34580(HOE34580);N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1’H-[2,5’-bibenzo[d]imidazol]-2’-yl)aniline;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1’H-[2,5’-bibenzo[d]imidazol]-2’-yl)anilineCAS號(hào)23555-00-2分子式C27H29N7分子量451.57EINECS號(hào)相關(guān)類別BenzimidazoleMol文件23555-00-2.mol結(jié)構(gòu)式HOECHST34580性質(zhì)熔點(diǎn)>300℃沸點(diǎn)733.2±70.0°C(Predicted)密度1.280±0.06g/cm3(Predicted)儲(chǔ)存條件2-8°C(protectfromlight)溶解度溶于二甲亞砜、水酸度系數(shù)(pKa)10.97±0.10,mostacidic,temperature:25°C;7.66±0.42,mostbasic(at25℃)形態(tài)Chemicalbook粉末顏色黃色到綠色最大波長(zhǎng)(λmax)392nm生物領(lǐng)域應(yīng)用Detectingmalariainfectedredbloodcells,polynucleotides;nucleicacidamplification;nucleicacidsequencingHOECHST34580用途與合成方法生物活性Hoechst34580(HOE34580)是一種具有細(xì)胞滲透性的藍(lán)色熒光染料，用于染色DNA和細(xì)胞核。Hoechst34580也是一種治療阿爾茨海默病的良好候選者，通過(guò)抑制amyloidbeta(Aβ)的形成，其IC50值為0.86μM。靶點(diǎn)TargetValueAβ(Cell-freeassay)0.86μM體外研究Hoechst34580preferstolocatenearhydrophobicregionswithbindingaffinitywiththeinhibitionconstantIC50of0.86±0.05μMforHoechst34580.Hoechst34580isagoodcandidatefortreatingtheAlzheimer’sdiseasebyinhibitingAβformation.50μMAβ42solutionsco-incubatedwith100,25,12.5,3.125,0.78,and0.1,0.01μMHoechst34580at37°Cfor70h.Hoechst34580caninhibittheaggregationofAβ42inadose-dependentmanner.Andthehalf-maximalconcentration(IC50)isexamined.TheIC50isobtainedbymeasuringtheconcentrationofHoechst34580whilemaintainingtheAβ42concentrationwhichgave0.86±0.05μMforHoechst34580. |
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聯(lián)系人： |
金經(jīng)理 |
地 址： |
湖北省武漢市東湖新技術(shù)開(kāi)發(fā)區(qū)光谷大道03號(hào) |
郵 編： |
430000 |
電 話： |
18995560451 |
手 機(jī)： |
15102708508 |
傳 真： |
18995560451 |
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www.hbdhchem.com |
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