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8-O-乙酰山梔苷甲酯 |
| CAS No.: |
57420-46-9 |
| 分子式： |
C19H28O12 |
| 分子量： |
448.42 |
| 備注： |
中文名稱8-O-乙酰山梔苷甲酯中文同義詞8-O-ACETYLSHANZHISIDEMETHYLESTER8-O-乙酰山梔苷甲酯;8-O-乙酰山梔苷甲酯(標(biāo)準(zhǔn)品);8-O-乙酰山梔苷甲酯;8-O-乙酰山梔苷甲酯,來(lái)源于獨(dú)一味;8-O-乙酰山梔苷甲酯,>98%;8-O-乙酰山梔苷甲酯(對(duì)照品);(1S,4AS,5R,7S,7AS)-7-乙酰氧基-5-羥基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羥基-6-(羥甲基)四氫-2H-吡喃-2-基)氧基)-1,4A,5,6,7,7A-六氫環(huán)戊并[C]吡喃-4-羧酸甲酯英文名稱8-O-acetylshanzhisidemethylester英文同義詞(1S)-1α-(β-D-Glucopyranosyloxy)-5α-hydroxy-7α-acetoxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylicacidmethylester;1α-(β-D-Glucopyranosyloxy)-7α-acetoxy-5α-hydroxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylicacidmethylester;7α-Acetoxy-1α-(β-D-glucopyranosyloxy)-1,4aα,5,6,7,7aα-hexahydro-5α-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylicacidmethylester;Barlerin;O-AcetylShanzhisideMethylEster,8-;8-AcetylshanzhisideMethylester;UMbroside;8-O-Acetylshanzhisidemethylester,98%,fromLamiophlomisrotata(Benth.exHook.f.)KudCAS號(hào)57420-46-9分子式C19H28O12分子量448.42EINECS號(hào)相關(guān)類別分析試劑標(biāo)準(zhǔn)品;中藥對(duì)照品;標(biāo)準(zhǔn)品;植物提取物;對(duì)照品;植提標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品-對(duì)照品;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品;環(huán)烯醚萜;標(biāo)準(zhǔn)品，對(duì)照品;chemicalreagent;pharmaceuticalintermediate;phytochemical;referencestandardsfromChinesemedicinalherbs(TCM).;standardizedherbalextractMol文件57420-46-9.mol結(jié)構(gòu)式8-O-乙酰山梔苷甲酯性質(zhì)沸點(diǎn)634.2±55.0°C(Predicted)密度1.52溶解度溶于甲烷形態(tài)粉末酸度系數(shù)(pKa)12.80±0.70(Predicted)顏色白色8-O-乙酰山梔苷甲酯用途與合成方法生物活性Barlerin(8-O-Acetylshanzhisidemethylester)是從中國(guó)西藏民間藥用植物中分離出的環(huán)孢菌素葡萄糖苷。Barlerin(8-O-AChemicalbookcetylshanzhisidemethylester)可以抑制NF-κB活性。靶點(diǎn)TargetValueNF-κB()體外研究TreatmentofSH-SY5YcellswithBarlerin(8-O-Acetylshanzhisidemethylester)blocksTNF-α-inducednucleartranscriptionfactorκB(NF-κB)activationanddecreaseshigh-mobilitygroupbox-1(HMGB-1)expression..TreatmentofH9c2cellswithBarlerin(8-O-Acetylshanzhisidemethylester)9μMblocksTNF-α-inducedNF-κBphosphorylationbyblockingHigh-mobilitygroupbox1(HMGB1)expression.體內(nèi)研究Barlerin(8-O-Acetylshanzhisidemethylester)40mg/kgdemonstratessignificantneuroprotectiveeffectevenafterdelayedadministrationat4hrafterI/R.Barlerin40mg/kgattenuatesthehistopathologicaldamage,decreasesbrainswelling,inhibitsNF-κBactivationandreducesHMGB-1expressioninischaemicbraintissue.Barlerin(8-O-Acetylshanzhisidemethylester)significantlypromotesangiogenesisintheischaemicbrainandimprovesfunctionaloutcomeafterstroke.Barlerinalsosignificantlyincreasesvascularizationcomparedwithvehicletreatment.ItincreasestheexpressionofVEGF,Ang1,phosphorylationofTie2andAktVEGF.Barlerin(8-O-Acetylshanzhisidemethylester)significantlyshortenscapillarybloodclottingtimeandreducesbloodlossvolume,butdoesnotinfluencemiceactivatedpartialthromboplastintime,prothrombintimeorthrombintime.Itsignificantlyprolongseuglobulinclotlysistimeinhyperfibrinolysismice.化學(xué)性質(zhì)類白色結(jié)晶粉末，易溶于甲醇乙醇，來(lái)源于獨(dú)一味。用途8-O-乙酰山梔苷甲酯具有止血鎮(zhèn)痛的作用。用途用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。藥理藥效:有活化淤血、止痛止血。 |
| 結(jié)構(gòu)式： |
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聯(lián)系人： |
金經(jīng)理 |
地 址： |
湖北省武漢市東湖新技術(shù)開(kāi)發(fā)區(qū)光谷大道03號(hào) |
郵 編： |
430000 |
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18995560451 |
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15102708508 |
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