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(+)-兒茶素,兒茶酚,兒茶酸,鄰苯二酚 |
| CAS No.: |
225937-10-0 |
| 分子式： |
C15H16O7 |
| 分子量： |
308.28 |
| 備注： |
中文名稱(+)-兒茶素,兒茶酚,兒茶酸,鄰苯二酚中文同義詞(+)-兒茶素(一水物);(2R,3S)-2-(3,4-二羥基苯基)-3,4-二氫-1(2H)-苯并吡喃-3,5,7-三醇一水物;(+)-兒茶素,兒茶酚,兒茶酸,鄰苯二酚;D(+)-兒茶精;D(+)-兒茶素(四水);D(+)-兒茶酸;反式-3,3ˊ,4ˊ,4,7-五羥基黃烷;四水合-D(+)兒茶素英文名稱(+)-CATECHINHYDRATE英文同義詞FK-027-13C,15N2;FR-17027-13C,15N2;(+)-Catechinhydrate>=96.0%(suMofenantioMers,HPLC);(2R,3S)-2-(3,4-Dihydroxyphenyl)-chroman-3,5,7-triolhydrate;2-keto-4-methyl-6-phenyl-3,6-dihydro-1H-pyrimidine-5-carboxylicacidmethylester;4-methyl-2-oxo-6-phenyl-3,6-dihydro-1H-pyrimidine-5-carboxylicacidmethylester;BAS00381104;EU-0067758CAS號225937-10-0分子式C15H16O7分子量308.29EINECS號684-232-3相關類別植提;標準品;分析標準品;植物提取物;植物生化提取物;小分子抑制劑;小分子抑制劑，天然產物;細胞生物;診斷試劑;各種化學試劑;微生物;植物激素及核酸類;chemicalreagent;pharmaceuticalintermediate;phytochemical;referencestandardsfromChinesemedicinalherbs(TCM).;standardizedherbalextract;Inhibitors;生化試劑-植物激素及核酸類;標準品-中藥標準品;對照品Mol文件225937-10-0.mol結構式(+)-兒茶素,兒茶酚,兒茶酸,鄰苯二酚性質熔點175-177°C(anhydrous)(lit.)比旋光度26o(C=1INH2O)儲存條件2-8°C溶解度乙醇：可溶50mg/mL形態(tài)粉末顏色黃色至黃色帶棕褐色旋光性(opticalactivity)[α]/D+26±2°,c=1inH2OMerck13,1912BRN3595244CAS數據庫225937-10-0(CASDataBaseReference)(+)-兒茶素,兒茶酚,兒茶酸,鄰苯二酚用途與合成方法生物活性(+)-Catechinhydrate抑制環(huán)加氧酶-1(COX-1),IC50為1.4μM。靶點COX-11.4μM(IC50)體外研究(+)-Catechinexhibits>95%inhibitoryactivityat70μg/mLChemicalbookagainstcyclooxygenase-1(COX-1)withanIC50of1.4μM.Adose-dependentreductionincolorisobservedafter24hoursoftreatmentwith(+)-Catechin,and54.76%ofthecellsaredeadatthehighestconcentrationof(+)-Catechintested(160μg/mL)whereastheIC50of(+)-Catechinisachievedat127.62μg/mL(+)-Catechin.Adose-andtime-dependentincreaseintheinductionofapoptosisisobservedwhenMCF-7cellsaretreatedwith(+)-Catechin.Whencomparetothecontrolcellsat24hours,40.7and41.16%ofthecellstreatedwith150μg/mLand300μg/mL(+)-Catechin,respectively,undergoapoptosis.TheexpressionlevelsofCaspase-3,-8,and-9andp53inMCF-7cellstreatedwith150μg/mL(+)-Catechinfor24hincreaseby5.81,1.42,3.29,and2.68fold,respectively,ascomparetothelevelsinuntreatedcontrolcells.體內研究Animalstreatedwith(+)-Catechinatthelowesttesteddose,i.e.,50mg/kg,p.o.havespentcomparativelymoretimeinexploringthenovelobjectinthechoicetrial,however,thedifferenceisnotstatisticallysignificant.(+)-Catechinpreventsthetime-inducedepisodicmemorydeficitsinadose-dependentmanner,themosteffectivebeing200mg/kg,p.o..Treatmentwith(+)-CatechinpreventstheriseinMPOlevelcomparetoDOXalonetreatmentgroup(21.98±9.44and36.76±4.39%inthehippocampusandthefrontalcortexrespectively).用途黃酮類抗氧劑，來自植物，自由基清道夫，阻止游離自由基對各種生物系統(tǒng)引起的傷害。 |
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