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血卟啉二鹽酸鹽 |
| CAS No.: |
17696-69-4 |
| 分子式： |
C34H40Cl2N4O6 |
| 分子量： |
671.61 |
| 備注： |
中文名稱血卟啉二鹽酸鹽中文同義詞血卟啉IX二氯化氫;鹵代卟啉鹽酸鹽;血卟啉二鹽酸鹽;二鹽酸血紫素;血卟啉鹽酸鹽;血卟啉鹽酸鹽(一水);血紫素鹽酸鹽;鹽酸血紫素英文名稱HEMATOPORPHYRINDIHYDROCHLORIDE英文同義詞21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;21h,23h-porphine-2,18-propanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionicacid;acido1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionicodiclor;ematoporfirina;HEMATOPORPHYRINIXDIHYDROCHLORIDE;HEMATOPORPHYRINDIHYDROCHLORIDE;HAEMATOPORPHYRINDIHYDROCHLORIDECAS號17696-69-4分子式C34H39ClN4O6分子量635.16EINECS號241-699-4相關(guān)類別醫(yī)藥原料;NaturalPorphyrinsandDerivitives;Porphyrins;Biochemistry;MiscellaneousBiochemicals;porphine(porphyrin)ligandMol文件17696-69-4.mol結(jié)構(gòu)式血卟啉二鹽酸鹽性質(zhì)儲存條件Inertatmosphere,RoomTemperature溶解度可溶于DMSO（少許）、甲醇（少許）形態(tài)固體顏色深紅色水溶解性Insolubleinwater.Solubleinpyridine(5%).Merck14,4636BRN78957穩(wěn)定性吸濕性EPA化學(xué)物質(zhì)信息21H,23H-Porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-,dihydrochloride(17696-69-4)血卟啉二鹽酸鹽用途與合成方法應(yīng)用有研究表明血卟啉二鹽酸鹽可用于制備具有高結(jié)晶速率的樹脂組合物，其包含聚呋喃二甲酸亞烷基酯(polyalkylenefurandicarboxylate)樹脂和卟啉化合物。該聚呋喃二甲酸亞烷基酯樹脂優(yōu)選為聚呋喃二甲酸亞丁基酯樹脂。該卟啉化合物優(yōu)選為血卟啉二鹽酸鹽(hematoporphyrindihydrochloride)。生物活性Hematoporphyrindihydrochloride(HematoporphyrinIXdihydrochloride)是一種光敏劑，是血紅素結(jié)合蛋白親和色譜底物。當(dāng)暴露于紅光下時，Hematoporphyrindihydrochloride可以誘導(dǎo)U87膠質(zhì)瘤細(xì)胞凋Chemicalbook亡，并降低體內(nèi)腫瘤的生長。體外研究Hematoporphyrin(20-120nM;60min)dose-dependentlyinhibitscellviabilityinU87andU251gliomacells,withIC50sof85and166nM,respectively.Hematoporphyrin(85nM;60min)inducescellapoptosisviainductionofROSinU87cells.Hematoporphyrin(85nM;60min)inducesmorphologicalchangesofU87cellsundertheredlight,includingshrinking,fragmentation.CellViabilityAssayCellLine:U87andU251cellsConcentration:20,40,60,80,100,120nMIncubationTime:60minResult:Inhibitedcellviabilityinadose-dependentmanner.Wasmoreeffectiveundertheredlightthanwhitelight.ApoptosisAnalysisCellLine:U87cellsConcentration:85nMIncubationTime:60minResult:InducedapoptoticnucleiinU87cellswithlowcelldensity.InducedtheROSanddecreasedthemitochondrialmembranepotential.體內(nèi)研究Hematoporphyrin(5-10mg/kg;i.p.for2months)withtheirradiationofredlightrapidlydecreasesthetumorsizeofrats,duetonecrosiscausedbothbydirectactionofthephotoactivatedporphyrinonthetumorcellsandbysecondaryeffectsonbloodvessels.AnimalModel:Wistaralbinoratsofbothsexes(20d;60-80g)bearingasubcutaneoussolidYoshidahepatomaAH-130Dosage:5,10mg/kgAdministration:I.p.dailyduringtheinitial10daysandbiweeklyforthenext2monthsResult:Notumorcouldbepalpatedafewdaysafterexposureoftheratstolight.Theskinhealedcompletelyandregrowthofthehairoccurred.Massivecoagulationnecrosisofthetumor24hafterphototreatment(×40). |
| 結(jié)構(gòu)式： |
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聯(lián)系人： |
金經(jīng)理 |
地 址： |
湖北省武漢市東湖新技術(shù)開發(fā)區(qū)光谷大道03號 |
郵 編： |
430000 |
電 話： |
18995560451 |
手 機(jī)： |
15102708508 |
傳 真： |
18995560451 |
Q Q： |
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www.hbdhchem.com |
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