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奧替尼啶鹽酸鹽 |
| CAS No.: |
70775-75-6 |
| 分子式： |
C36H64Cl2N4 |
| 分子量： |
623.82616 |
| 備注： |
中文名稱奧替尼啶鹽酸鹽中文同義詞奧替尼啶奧克太啶(雙鹽酸鹽);奧克太啶鹽酸鹽;奧替尼啶鹽酸鹽;奧替尼啶二鹽酸鹽;奧替尼啶雜質;奧替尼啶,奧克太啶;奧替尼定鹽酸鹽;鹽酸奧替尼啶英文名稱Octenidinedihydrochloride英文同義詞N,N’-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis(1-octanamine)dihydrochloride;N,N’-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium)dichloride;Octenidinehydrochloride;OCTENIDINEDIHYDROCHLORIDE;N,N’-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-1-octanaMineHydrochloride;N’-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylaMMoniuM)dichloride;1-OctanaMine,N,N’-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-,hydrochloride(1:2);ocenidinedihydrochlorideCAS號70775-75-6分子式C36H64Cl2N4分子量623.82616EINECS號274-861-8相關類別原料藥;醫(yī)藥原料;原料藥;化妝品原料;抗菌;新型抗菌;醫(yī)藥原料藥;合成;醫(yī)藥抗菌劑;醫(yī)用原料;醫(yī)藥化工原料;化工原料;化工中間體;Amines;Heterocycles;Intermediates&FineChemicals;Pharmaceuticals;原料;其他原料;化學試劑;化工品Mol文件70775-75-6.mol結構式奧替尼啶鹽酸鹽性質熔點215-217℃密度1.046[at20℃]蒸氣壓0Paat25℃儲存條件Keepindarkplace,InertatmospheChemicalbookre,Roomtemperature溶解度溶于二甲基亞砜和甲醇。形態(tài)固體顏色白色至類白色水溶解性14.2g/Lat20℃Merck14,6754穩(wěn)定性吸濕性InChIKeySMGTYJPMKXNQFY-UHFFFAOYSA-NSMILES[N+]1(CCCCCCCCCC[N+]2C=CC(NCCCCCCCC)=CC=2)=CC=C(NCCCCCCCC)C=C1.[Cl-].[Cl-]LogP1.5at23℃奧替尼啶鹽酸鹽用途與合成方法生物活性Octenidine是一種陽離子型表面活性劑，對革蘭氏陽性和陰性的細菌具有活性。體外研究Octenidineconcentrationsoflessthan1.5μM(0.94μg/mL)causesagreaterthan99%reductionoftestedmicrobialpopulationwithin15min.Staphylococcusepidermidisisthemostsusceptibleofthetestorganisms,andE.coliandC.albicansaretheleastsusceptible.體內研究Theantimicrobialactivityofoctenidinehydrochloride(OCT)ismaintainedwhenappliedtotheskinofthehandsandfeetofcynomolgusmonkeys.Aqueousoctenidine,ataconcentrationof0.2to1.6%reducesresidentmicroflorapopulationsfrom90to99.98%.Asignificantreductioninplaquescoreisobservedonthebuccaltoothsurfacesafterdailytopicalapplicationof1%solutionsofoctenidineandchlorhexidinefor7d;octenidineismoreeffectivethanchlorhexidine. |
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