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油酰單乙醇胺 |
| CAS No.: |
111-58-0 |
| 分子式： |
C20H39NO2 |
| 分子量： |
325.53 |
| 備注： |
中文名稱(chēng)油酰單乙醇胺中文同義詞N-(2-羥乙基)-(Z)-9-十八烯酰胺;油酰乙醇胺(OEA);油酰乙醇胺;油酰單乙醇胺;硝酸二十酯;油酰胺MEA;油酰乙醇胺(CAS號(hào):111-58-0);油酰乙醇胺(油酰單乙醇胺)英文名稱(chēng)OleoylEthanolamide英文同義詞N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide;ODA;OLEICACID-2,6-DIISOPROPYLANILIDE;N-[2,6-BIS(1-METHYLETHYL)PHENYL]-9Z-OCTADECENAMIDE;N-Oleoylethanolamine,~98%;9Z-OCTADECENOYLETHANOLAMIDE;C18:1ANANDAMIDE;C18:1anandamide;Oleoylethanolamide(OEA)CAS號(hào)111-58-0分子式C20H39NO2分子量325.53EINECS號(hào)203-884-8相關(guān)類(lèi)別催化劑及助劑;橡膠助劑;脂類(lèi);氮化合物;醫(yī)藥原料;化工中間體;原料;產(chǎn)品;食品添加劑;對(duì)照品;Intracellularreceptor;FluorobenzeneMol文件111-58-0.mol結(jié)構(gòu)式油酰單乙醇胺性質(zhì)熔點(diǎn)63-64°C沸點(diǎn)496.4±38.0°C(Predicted)密度0.915±0.06g/cm3(Predicted)儲(chǔ)存條件-20°C溶解度可溶于DMSO（高達(dá)25mg/ml）或乙醇（高達(dá)35mg/ml）形態(tài)白色固體酸度系數(shù)(pKa)14.49±0.10(Predicted)顏色白色穩(wěn)定性自購(gòu)買(mǎi)之日起2年內(nèi)保持穩(wěn)定。DMSO或乙醇溶液可在-20°C下保存長(zhǎng)達(dá)1個(gè)月。InChIInChI=1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-InChIKeyBOWVQLFMWHZBEF-KTKRTIGZSA-NSMILESC(NCCO)(=O)CCCCCCC/C=CCCCCCCCCLogP6.406(est)CAS數(shù)據(jù)庫(kù)111-58-0(CASDataBaseReference)EPA化學(xué)物質(zhì)信息9-Octadecenamide,N-(2-hydroxyethyl)-,(9Z)-(111-58-0)油酰單乙醇胺用途與合成方法用途油酰單乙醇胺是過(guò)氧化物酶體增殖物激活受體α(PPAR-α)的激動(dòng)劑。N-油酰乙醇酰胺產(chǎn)生腸道信號(hào)，刺激中樞多巴胺活動(dòng)，在熱量-自我平衡和快樂(lè)-自我平衡之間建立聯(lián)系。油酰乙醇酰胺被認(rèn)為是胃旁路手術(shù)成功的分子機(jī)制。N-油酰乙醇酰胺是一種選擇性GPR55激動(dòng)劑。生物活性O(shè)leoylethanolamide是一種高親和力的內(nèi)源性PPAR-α激動(dòng)劑，可用于肥胖和動(dòng)脈硬化的相關(guān)研究。靶點(diǎn)HumanEndogenousMetabolitePPAR-α體外研究Oleoylethanolamide(OEA),anendogenousPPAR-αligand,attenuatesliverfibrosistargetinghepaticstellatecells.OleoylethanolamidesuppressesTGF-β1induceChemicalbookdhepaticstellatecells(HSCs)activationinvitroviaPPAR-α.ToassesstheimpactofOleoylethanolamideonHSCsactivation,theexpressionlevelsofα-SMAandCol1ainTGF-β1-stimulatedHSCsareexaminedbyqPCR.ThemRNAlevelsofα-SMAandCol1aaremarkedlyinducedinthegroupofCFSCcellswithTGF-β1(5ng/mL)stimulationfor48h,whilethemRNAlevelsaresuppressedwhentreatedwithOleoylethanolamideinadose-dependentmanner.ImmunofluorescenceandwesternblotresultsshowthatOleoylethanolamidetreatmentdose-dependentlyinhibitstheproteinexpressionofα-SMA,themarkerofHSCactivation.TheinhibitoryeffectsofOleoylethanolamideonHSCsactivationarecompletelyblockedbyPPAR-αantagonistMK886(10μM).Moreover,themRNAandproteinexpressionlevelsofPPAR-αaredown-regulatedwithTGF-β1stimulation,whileOleoylethanolamidetreatmentrestoresthesechangesindose-dependentmanner.Inaddition,thephosphorylationofSmad2/3isupregulatedinthepresenceofTGF-β1stimulation,consistentwiththeobservedeffectsonHSCactivation,whileOleoylethanolamide(10μM)reducesthephosphorylationofSmad2/3inCFSCsimulatedwithTGF-β1.體內(nèi)研究Oleoylethanolamide(OEA)cansignificantlysuppressthepro-fibroticcytokineTGF-β1negativelyregulategenesintheTGF-β1signalingpathway(α-SMA,collagen1a,andcollagen3a)inmicemodelsofhepaticfibrosis.TreatmentwithOleoylethanolamide(5mg/kg/day,intraperitonealinjection,i.p.)significantlyattenuatestheprogressofliverfibrosisinbothtwoexperimentalanimalmodelsbyblockingtheactivationofhepaticstellatecells(HSCs). |
| 結(jié)構(gòu)式： |
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聯(lián)系人： |
金經(jīng)理 |
地 址： |
湖北省武漢市東湖新技術(shù)開(kāi)發(fā)區(qū)光谷大道03號(hào) |
郵 編： |
430000 |
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18995560451 |
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